Principal Translational Scientist

Permanent
Cambridgeshire
Posted 7 years ago

Position: Principal Translational Scientist

Location: Cambridge

Salary: Competitive

 

An exciting opportunity to join a growing Biotechnology company in Cambridge as a Principal Translational Scientist.

 

The Role

 

As the Principal Translational Scientist, you’ll assist in the development and implementation of the translational strategy to our novel pipeline of early phase bispecific mAb2 molecules for immune-oncology. You’ll guide internal and external teams to produce quantitative translational datasets to enable the selection of best-in-class molecules and a well-defined data package to enable successful clinical development

 

Key Responsibilities:

  • Responsible for providing technical and scientific contribution to the biomarker strategy for multiple IO bispecific mAb projects
  • Work as part of a multidisciplinary team to develop the translational and clinical biomarker strategy
  • Liaise closely with preclinical pharmacology and discovery groups to characterize the fundamental biology of targets and translation across species to ensure appropriate endpoints are measured for target engagement and pharmacodynamic effects.
  • Perform the appropriate scholarship required to develop hypothesis driven approaches to the targeted use of quantitative biomarkers
  • Oversee the technical and operational aspects of mechanistic biochemical biomarker analysis (e.g. sample collection through to data generation and interpretation)
  • Continually assess the latest technologies available and provide input to the internal and external capabilities required to support the portfolio needs.
  • To represent the client at external meetings including contributions at meetings by way of presentations, scientific committee representation and publications.
  • Drive a culture of inclusivity and active engagement with translational goals and thereby translational understanding across the company.

 

You

Ideally you’ll have a PhD in Life Sciences and be an experienced biomarker scientist with demonstrated ability supporting translational and clinical mechanistic biochemical biomarker activities to assess target exposure, engagement/ occupancy and pharmacodynamic effects in collaboration with internal and external partners e.g CROs, consultants, and collaborating organisations.

You’ll also have experience utilizing data e.g via statistical analysis and data visualisation, from a broad arrange of technology platforms to assess biomarkers including but not limited to immunoassays, flow cytometry, omics platforms etc and proven ability to drive the implementation of a biomarker strategy in preclinical or clinical studies.

Experience working with technical staff to ensure assays are developed to ensure they are fit for purpose to support drug development programs and experience working within a matrix environment with a wide range of drug discovery and development stakeholders to include Preclinical Pharmacology, Protein Sciences, Clinical development etc is essential.

Company

 

A leading Biotechnology Company who have gone through significant growth and are focused on the development of Bispecific Antibodies for the treatment of serious diseases including Immune Oncology.

 

Salary and Benefits

 

Salaries are very competitive and discussed during the interview process with benefits including Pension Scheme, Life Assurance and Private Medical Insurance. This company has gone through significant growth the past 12 months and they offer great career progression opportunities.

 

Apply Now

 

To be considered for the Principal Translational Scientist and have the chance to work for a cutting edge company please send your CV to Natasha Robbins at Fuse Science Recruitment via the apply now button

Job Features

Job CategoryBiopharmaceutical, Biotechnology

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